2. Signaling Pathways
  3. PROTAC
  4. Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Related Products

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Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.

The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

Target Protein Ligand-Linker Conjugates Related Products (71):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-176187
    DDR1 ligand 1-piperidine 3081612-71-4
    DDR1 ligand 1-piperidine is a target protein ligand and linker conjugate, which can be used for the synthesis of PROTAC DDR1 degrader-1 (HY-176184).
    DDR1 ligand 1-piperidine
  • HY-176788
    EGFR Ligand-Linker Conjugates 1 2768472-86-0
    EGFR Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605).
    EGFR Ligand-Linker Conjugates 1
  • HY-176335
    TBK1 ligand 2-C-O-C4-O-C3-O-C-amide 2052306-12-2
    TBK1 ligand 2-C-O-C4-O-C3-O-C-amide is a conjugate of TBK1 ligand and linker, which can be used in the synthesis of PROTAC TBK1 degrader-2 (HY-112557).
    TBK1 ligand 2-C-O-C4-O-C3-O-C-amide
  • HY-147050
    Ahx-DM1 1702356-21-5
    Ahx-DM1 (compound 2A) is a conjugate of protein/peptide which can be combined with a therapeutic, diagnostic or labelling agent.
    Ahx-DM1
  • HY-130991A
    K-Ras ligand-Linker Conjugate 6 formate 98.93%
    K-Ras ligand-Linker Conjugate 6 formate incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 formate can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
    K-Ras ligand-Linker Conjugate 6 formate
  • HY-178046
    OSBP ligand-Linker Conjugate 1
    OSBP ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034).
    OSBP ligand-Linker Conjugate 1
  • HY-172067
    ER ligand-9 3026011-20-8
    ER ligand-9 is a conjugate of an estrogen receptor (Estrogen Receptor/ERR) and a linker, which can be used to synthesize PROTAC ERD-1233 (HY-169367).
    ER ligand-9
  • HY-175268
    PXR ligand-Linker Conjugate 1
    PXR ligand-Linker Conjugate 1 is a conjugate of PXR ligand and linker, which can be used to synthesize PROTAC MI1013 (HY-175266).
    PXR ligand-Linker Conjugate 1
  • HY-175860
    KRAS G12D ligand-Linker Conjugate 2
    KRAS G12D ligand-Linker Conjugate 2 is a conjugate of the KRAS (G12D) ligand (HY-175859) and the linker (HY-168698). KRAS G12D ligand-Linker Conjugate 2 can be used for synthesizing PROTAC KRAS (G12D) degrader ASP-3082 (HY-157505).
    KRAS G12D ligand-Linker Conjugate 2
  • HY-176365
    Palbociclib-C4-Boc 2139329-48-7
    Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK4/6 Palbociclib (HY-50767) and a PROTAC linker (HY-W007803), which recruits E3 ligases. Palbociclib-C4-Boc can be used for synthesis of PROTAC BSJ-03-204 (HY-136250).
    Palbociclib-C4-Boc
  • HY-176802
    Oxide-DFHBI-demethyl-C6-NH2
    Oxide-DFHBI-demethyl-C6-NH2 is a Target Protein Ligand-Linker Conjugate that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397).
    Oxide-DFHBI-demethyl-C6-NH2
  • HY-176797
    SMARCA2/4 Ligand-Linker Conjugate 2 2380272-29-5
    SMARCA2/4 Ligand-Linker Conjugate 2 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC AU-15330 (HY-145388).
    SMARCA2/4 Ligand-Linker Conjugate 2
  • HY-170854
    RET Ligand-Linker Conjugate-1
    RET Ligand-Linker Conjugate-1 is the conjugate composed of a RET ligand and a linker. RET Ligand-Linker Conjugate-1 can be used for synthesis of QZ2135 (HY-170852).
    RET Ligand-Linker Conjugate-1
  • HY-163019
    EN884 2189497-60-5
    EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs).
    EN884
  • HY-175551
    HPK1 ligand-Linker Conjugate 1 3061690-80-7
    HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547). PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity.
    HPK1 ligand-Linker Conjugate 1
  • HY-176364
    AZD9496-O-C3-O-C3-O-C-acid 2361117-48-6
    AZD9496-O-C3-O-C3-O-C-acid is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ERα (HY-12870) and a PROTAC linker, which recruits E3 ligases. AZD9496-O-C3-O-C3-O-C-acid can be used for synthesis of PROTAC AZ'6421 (HY-135312).
    AZD9496-O-C3-O-C3-O-C-acid
  • HY-174409
    HDAC6 ligand-Linker Conjugate 1
    HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5 (HY-174401).
    HDAC6 ligand-Linker Conjugate 1
  • HY-168682
    Adamantane-Butyl alcohol 31685-38-8
    Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. Adamantane-Butyl alcohol is the linker for LL-K8-22 (PROTAC CDK8-cyclin C, HY-149209) and HyT.
    Adamantane-Butyl alcohol
  • HY-175333
    c-Met ligand-Linker Conjugate 1
    c-Met ligand-Linker Conjugate 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320).
    c-Met ligand-Linker Conjugate 1
  • HY-175726
    BRAF ligand-Linker Conjugate 1 3094183-96-4
    BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435).
    BRAF ligand-Linker Conjugate 1